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The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
G protein-coupled receptors (GPCRs) mediate the majority of physiologic responses to hormones and neurotransmitters. However, many GPCRs exhibit varying degrees of agonist-independent G protein activation. This phenomenon is referred to as basal or constitutive activity. For many of these GPCRs, dru...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685739/ https://ncbi.nlm.nih.gov/pubmed/19470481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811437106 |
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