The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

G protein-coupled receptors (GPCRs) mediate the majority of physiologic responses to hormones and neurotransmitters. However, many GPCRs exhibit varying degrees of agonist-independent G protein activation. This phenomenon is referred to as basal or constitutive activity. For many of these GPCRs, dru...

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Main Authors: Yao, Xiao Jie, Vélez Ruiz, Gisselle, Whorton, Matthew R., Rasmussen, Søren G. F., DeVree, Brian T., Deupi, Xavier, Sunahara, Roger K., Kobilka, Brian
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2009
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685739/
https://ncbi.nlm.nih.gov/pubmed/19470481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811437106
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