Detection of G Protein-selective G Protein-coupled Receptor (GPCR) Conformations in Live Cells

Although several recent studies have reported that GPCRs adopt multiple conformations, it remains unclear how subtle conformational changes are translated into divergent downstream responses. In this study, we report on a novel class of FRET-based sensors that can detect the ligand/mutagenic stabili...

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Main Authors: Malik, Rabia U., Ritt, Michael, DeVree, Brian T., Neubig, Richard R., Sunahara, Roger K., Sivaramakrishnan, Sivaraj
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2013
Ábhair:
Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682522/
https://ncbi.nlm.nih.gov/pubmed/23629648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.464065
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