Detection of G Protein-selective G Protein-coupled Receptor (GPCR) Conformations in Live Cells

Although several recent studies have reported that GPCRs adopt multiple conformations, it remains unclear how subtle conformational changes are translated into divergent downstream responses. In this study, we report on a novel class of FRET-based sensors that can detect the ligand/mutagenic stabili...

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Autors principals: Malik, Rabia U., Ritt, Michael, DeVree, Brian T., Neubig, Richard R., Sunahara, Roger K., Sivaramakrishnan, Sivaraj
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682522/
https://ncbi.nlm.nih.gov/pubmed/23629648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.464065
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