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Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

Despite the crowded nature of the cellular milieu, ligand–GPCR–G protein interactions are traditionally viewed as spatially and temporally isolated events. In contrast, recent reports suggest the spatial and temporal coupling of receptor–effector interactions, with the potential to diversify downstr...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gupte, Tejas M., Ritt, Michael, Dysthe, Matthew, Malik, Rabia U., Sivaramakrishnan, Sivaraj
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811539/
https://ncbi.nlm.nih.gov/pubmed/31645561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12755-9
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