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Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

Despite the crowded nature of the cellular milieu, ligand–GPCR–G protein interactions are traditionally viewed as spatially and temporally isolated events. In contrast, recent reports suggest the spatial and temporal coupling of receptor–effector interactions, with the potential to diversify downstr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Gupte, Tejas M., Ritt, Michael, Dysthe, Matthew, Malik, Rabia U., Sivaramakrishnan, Sivaraj
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811539/
https://ncbi.nlm.nih.gov/pubmed/31645561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12755-9
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