Activation mechanism of the β(2)-adrenergic receptor

A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active and inactive functional states of GPCRs, these structures do not reveal the mechanism by...

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Autors principals: Dror, Ron O., Arlow, Daniel H., Maragakis, Paul, Mildorf, Thomas J., Pan, Albert C., Xu, Huafeng, Borhani, David W., Shaw, David E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219117/
https://ncbi.nlm.nih.gov/pubmed/22031696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110499108
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