Activation mechanism of the β(2)-adrenergic receptor

A third of marketed drugs act by binding to a G-protein-coupled receptor (GPCR) and either triggering or preventing receptor activation. Although recent crystal structures have provided snapshots of both active and inactive functional states of GPCRs, these structures do not reveal the mechanism by...

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Bibliografske podrobnosti
Main Authors: Dror, Ron O., Arlow, Daniel H., Maragakis, Paul, Mildorf, Thomas J., Pan, Albert C., Xu, Huafeng, Borhani, David W., Shaw, David E.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219117/
https://ncbi.nlm.nih.gov/pubmed/22031696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110499108
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