Structural Basis for Nucleotide Exchange in Heterotrimeric G Proteins

G protein–coupled receptors (GPCRs) relay diverse extracellular signals into cells by catalyzing nucleotide release from heterotrimeric G proteins, but the mechanism underlying this quintessential molecular signaling event has remained unclear. Here we use atomic-level simulations to elucidate the n...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Dror, Ron O., Mildorf, Thomas J., Hilger, Daniel, Manglik, Aashish, Borhani, David W., Arlow, Daniel H., Philippsen, Ansgar, Villanueva, Nicolas, Yang, Zhongyu, Lerch, Michael T., Hubbell, Wayne L., Kobilka, Brian K., Sunahara, Roger K., Shaw, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968074/
https://ncbi.nlm.nih.gov/pubmed/26089515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa5264
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