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Molecular determinants of α–synuclein mutants’ oligomerization and membrane interactions
Parkinson’s disease (PD) is associated with the formation of toxic α-synuclein oligomers and their penetration the cell membrane. Familial forms of PD are caused by the point mutations A53T, A30P, E46K, and H50Q. Artificial point mutations E35K and E57K also increase oligomerization and pore formati...
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| Publicado en: | ACS Chem Neurosci |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4944825/ https://ncbi.nlm.nih.gov/pubmed/25561023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500332w |
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