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Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD

The olfactory bulb (OB) is one of the first brain regions in Parkinson’s disease (PD) to contain alpha-synuclein (α-syn) inclusions, possibly associated with nonmotor symptoms. Mechanisms underlying olfactory synucleinopathy, its contribution to progressive aggregation pathology and nigrostriatal do...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Nuber, Silke, Tadros, Daniel, Fields, Jerel, Overk, Cassia Rose, Ettle, Benjamin, Kosberg, Kori, Mante, Michael, Rockenstein, Edward, Trejo, Margarita, Masliah, Eliezer
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324760/
https://ncbi.nlm.nih.gov/pubmed/24509835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1255-5
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