Molecular determinants of α–synuclein mutants’ oligomerization and membrane interactions

Parkinson’s disease (PD) is associated with the formation of toxic α-synuclein oligomers and their penetration the cell membrane. Familial forms of PD are caused by the point mutations A53T, A30P, E46K, and H50Q. Artificial point mutations E35K and E57K also increase oligomerization and pore formati...

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Udgivet i:ACS Chem Neurosci
Main Authors: Tsigelny, Igor F., Sharikov, Yuriy, Kouznetsova, Valentina L., Greenberg, Jerry P., Wrasidlo, Wolf, Overk, Cassia, Gonzalez, Tania, Trejo, Margarita, Spencer, Brian, Kosberg, Kori, Masliah, Eliezer
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944825/
https://ncbi.nlm.nih.gov/pubmed/25561023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500332w
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