Structural diversity of Alzheimer’s disease Aβ dimers and their role in oligomerization and fibril formation

Alzheimer’s disease (AD) is associated with the formation of toxic Aβ(42) oligomers and recent evidence supports a role for Aβ dimers as building blocks for oligomers. Molecular dynamics (MD) simulation studies have identified clans for the dominant conformations of Aβ(42) forming dimers; however, i...

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Gepubliceerd in:J Alzheimers Dis
Hoofdauteurs: Tsigelny, Igor F., Sharikov, Yuriy, Kouznetsova, Valentina L., Greenberg, Jerry P., Wrasidlo, Wolfgang, Gonzalez, Tania, Desplats, Paula, Michael, Sarah E., Trejo-Morales, Margarita, Overk, Cassia R., Masliah, Eliezer
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449729/
https://ncbi.nlm.nih.gov/pubmed/24240640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-131589
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