Structural diversity of Alzheimer’s disease Aβ dimers and their role in oligomerization and fibril formation

Alzheimer’s disease (AD) is associated with the formation of toxic Aβ(42) oligomers and recent evidence supports a role for Aβ dimers as building blocks for oligomers. Molecular dynamics (MD) simulation studies have identified clans for the dominant conformations of Aβ(42) forming dimers; however, i...

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Veröffentlicht in:J Alzheimers Dis
Hauptverfasser: Tsigelny, Igor F., Sharikov, Yuriy, Kouznetsova, Valentina L., Greenberg, Jerry P., Wrasidlo, Wolfgang, Gonzalez, Tania, Desplats, Paula, Michael, Sarah E., Trejo-Morales, Margarita, Overk, Cassia R., Masliah, Eliezer
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449729/
https://ncbi.nlm.nih.gov/pubmed/24240640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-131589
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