Neuroprotective effects of the anti‐cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders

BACKGROUND AND PURPOSE: Anti-retrovirals have improved and extended the life expectancy of patients with HIV. However, as this population ages, the prevalence of cognitive changes is increasing. Aberrant activation of kinases, such as receptor tyrosine kinases (RTKs) and cyclin-dependent kinase 5 (C...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Wrasidlo, Wolf, Crews, Leslie A, Tsigelny, Igor F, Stocking, Emily, Kouznetsova, Valentina L, Price, Diana, Paulino, Amy, Gonzales, Tania, Overk, Cassia R, Patrick, Christina, Rockenstein, Edward, Masliah, Eliezer
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290715/
https://ncbi.nlm.nih.gov/pubmed/25117211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12875
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