Neuroprotective effects of the anti‐cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders

BACKGROUND AND PURPOSE: Anti-retrovirals have improved and extended the life expectancy of patients with HIV. However, as this population ages, the prevalence of cognitive changes is increasing. Aberrant activation of kinases, such as receptor tyrosine kinases (RTKs) and cyclin-dependent kinase 5 (C...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Wrasidlo, Wolf, Crews, Leslie A, Tsigelny, Igor F, Stocking, Emily, Kouznetsova, Valentina L, Price, Diana, Paulino, Amy, Gonzales, Tania, Overk, Cassia R, Patrick, Christina, Rockenstein, Edward, Masliah, Eliezer
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290715/
https://ncbi.nlm.nih.gov/pubmed/25117211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12875
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