Structural diversity of Alzheimer’s disease Aβ dimers and their role in oligomerization and fibril formation

Alzheimer’s disease (AD) is associated with the formation of toxic Aβ(42) oligomers and recent evidence supports a role for Aβ dimers as building blocks for oligomers. Molecular dynamics (MD) simulation studies have identified clans for the dominant conformations of Aβ(42) forming dimers; however, i...

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Bibliografiske detaljer
Udgivet i:J Alzheimers Dis
Main Authors: Tsigelny, Igor F., Sharikov, Yuriy, Kouznetsova, Valentina L., Greenberg, Jerry P., Wrasidlo, Wolfgang, Gonzalez, Tania, Desplats, Paula, Michael, Sarah E., Trejo-Morales, Margarita, Overk, Cassia R., Masliah, Eliezer
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449729/
https://ncbi.nlm.nih.gov/pubmed/24240640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-131589
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