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Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

Parkinson’s disease (PD) and Dementia with Lewy bodies are common disorders of the aging population characterized by the progressive accumulation of α-synuclein (α-syn) in the CNS. Aggregation of α-syn into oligomers with a ring-like appearance has been proposed a role in toxicity. However, the mole...

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Main Authors: Tsigelny, Igor F., Sharikov, Yuriy, Wrasidlo, Wolfgang, Gonzalez, Tania, Desplats, Paula A., Crews, Leslie, Spencer, Brian, Masliah, Eliezer
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925782/
https://ncbi.nlm.nih.gov/pubmed/22251432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2012.08489.x
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