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Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

Parkinson’s disease (PD) and Dementia with Lewy bodies are common disorders of the aging population characterized by the progressive accumulation of α-synuclein (α-syn) in the CNS. Aggregation of α-syn into oligomers with a ring-like appearance has been proposed a role in toxicity. However, the mole...

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Detalhes bibliográficos
Main Authors: Tsigelny, Igor F., Sharikov, Yuriy, Wrasidlo, Wolfgang, Gonzalez, Tania, Desplats, Paula A., Crews, Leslie, Spencer, Brian, Masliah, Eliezer
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925782/
https://ncbi.nlm.nih.gov/pubmed/22251432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2012.08489.x
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