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Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

Parkinson’s disease (PD) and Dementia with Lewy bodies are common disorders of the aging population characterized by the progressive accumulation of α-synuclein (α-syn) in the CNS. Aggregation of α-syn into oligomers with a ring-like appearance has been proposed a role in toxicity. However, the mole...

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Bibliografske podrobnosti
Main Authors: Tsigelny, Igor F., Sharikov, Yuriy, Wrasidlo, Wolfgang, Gonzalez, Tania, Desplats, Paula A., Crews, Leslie, Spencer, Brian, Masliah, Eliezer
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925782/
https://ncbi.nlm.nih.gov/pubmed/22251432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2012.08489.x
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