Molecular determinants of α–synuclein mutants’ oligomerization and membrane interactions

Parkinson’s disease (PD) is associated with the formation of toxic α-synuclein oligomers and their penetration the cell membrane. Familial forms of PD are caused by the point mutations A53T, A30P, E46K, and H50Q. Artificial point mutations E35K and E57K also increase oligomerization and pore formati...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Neurosci
Asıl Yazarlar: Tsigelny, Igor F., Sharikov, Yuriy, Kouznetsova, Valentina L., Greenberg, Jerry P., Wrasidlo, Wolf, Overk, Cassia, Gonzalez, Tania, Trejo, Margarita, Spencer, Brian, Kosberg, Kori, Masliah, Eliezer
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944825/
https://ncbi.nlm.nih.gov/pubmed/25561023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500332w
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