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Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function

Many tumor-associated mutant p53 proteins gain new activities to promote tumorigenesis, which is termed as gain of function of mutant p53 (GOF). Currently, the mechanisms of mutant p53 GOF remain elusive. We recently identified the AAA+ ATPase pontin as a critical regulator of mutant p53 GOF, thus p...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell Oncol
Asıl Yazarlar: Zhao, Yuhan, Yue, Xuetian, Hu, Wenwei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905376/
https://ncbi.nlm.nih.gov/pubmed/27308598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1076587
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