A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis

Tumor suppressor p53 is the most frequently mutated gene in human tumors. Many tumor-associated mutant p53 (mutp53) proteins gain new tumor-promoting activities, including increased proliferation, metastasis and chemoresistance of tumor cells, which are defined as gain-of-functions (GOFs). Mutp53 pr...

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Udgivet i:Cell Discov
Main Authors: Yue, Xuetian, Zhao, Yuhan, Huang, Grace, Li, Jun, Zhu, Junlan, Feng, Zhaohui, Hu, Wenwei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088412/
https://ncbi.nlm.nih.gov/pubmed/27807478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.39
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