Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis

Tumor suppressor p53 is the most frequently mutated gene in human cancer. Mutant p53 (mutp53) not only loses the tumor suppressive activity of wild type p53, but often gains new oncogenic activities to promote tumorigenesis, defined as mutp53 gain of function (GOF). While the concept of mutp53 GOF i...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Cycle
Auteurs principaux: Yue, Xuetian, Wu, Fangnan, Li, Yanchen, Liu, Juan, Boateng, Michael, Mandava, Kranthi, Zhang, Cen, Feng, Zhaohui, Gao, Jimin, Hu, Wenwei
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2020
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469461/
https://ncbi.nlm.nih.gov/pubmed/32275841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1749790
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