Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression

Tumor suppressor p53 is frequently mutated in human cancer. Mutant p53 often promotes tumor progression through gain-of-function (GOF) mechanisms. However, the mechanisms underlying mutant p53 GOF are not well understood. In this study, we found that mutant p53 activates small GTPase Rac1 as a criti...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Yue, Xuetian, Zhang, Cen, Zhao, Yuhan, Liu, Juan, Lin, Alan W., Tan, Victor M., Drake, Justin M., Liu, Lianxin, Boateng, Michael N., Li, Jun, Feng, Zhaohui, Hu, Wenwei
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647935/
https://ncbi.nlm.nih.gov/pubmed/28947497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.301564.117
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