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Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function

Many tumor-associated mutant p53 proteins gain new activities to promote tumorigenesis, which is termed as gain of function of mutant p53 (GOF). Currently, the mechanisms of mutant p53 GOF remain elusive. We recently identified the AAA+ ATPase pontin as a critical regulator of mutant p53 GOF, thus p...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Oncol
Prif Awduron: Zhao, Yuhan, Yue, Xuetian, Hu, Wenwei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905376/
https://ncbi.nlm.nih.gov/pubmed/27308598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1076587
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