Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53

Tumor-suppressor p53 is frequently mutated in human cancers. Many tumor-associated mutant p53 (mutp53) proteins gain new functions in promoting tumorigenesis, defined as gain-of-function (GOF). The mechanisms for mutp53 GOF are not well understood. Here, we report Pontin, a highly conserved AAA+ ATP...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Zhao, Y, Zhang, C, Yue, X, Li, X, Liu, J, Yu, H, Belyi, V A, Yang, Q, Feng, Z, Hu, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648328/
https://ncbi.nlm.nih.gov/pubmed/25857266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.33
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