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Mutant p53 in cancer: accumulation, gain-of-function and therapy

Tumor suppressor p53 plays a central role in tumor suppression. p53 is the most frequently mutated gene in human cancer, and over half of human cancers contain p53 mutations. Majority of p53 mutations in cancer are missense mutations, leading to the expression of full-length mutant p53 protein. Whil...

詳細記述

保存先:
書誌詳細
出版年:J Mol Biol
主要な著者: Yue, Xuetian, Zhao, Yuhan, Xu, Yang, Zheng, Min, Feng, Zhaohui, Hu, Wenwei
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663274/
https://ncbi.nlm.nih.gov/pubmed/28390900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.03.030
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