Mutant p53 in cancer: accumulation, gain-of-function and therapy

Tumor suppressor p53 plays a central role in tumor suppression. p53 is the most frequently mutated gene in human cancer, and over half of human cancers contain p53 mutations. Majority of p53 mutations in cancer are missense mutations, leading to the expression of full-length mutant p53 protein. Whil...

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Bibliographic Details
Published in:J Mol Biol
Main Authors: Yue, Xuetian, Zhao, Yuhan, Xu, Yang, Zheng, Min, Feng, Zhaohui, Hu, Wenwei
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663274/
https://ncbi.nlm.nih.gov/pubmed/28390900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.03.030
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