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Mutant p53 in cancer: accumulation, gain-of-function and therapy
Tumor suppressor p53 plays a central role in tumor suppression. p53 is the most frequently mutated gene in human cancer, and over half of human cancers contain p53 mutations. Majority of p53 mutations in cancer are missense mutations, leading to the expression of full-length mutant p53 protein. Whil...
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| 出版年: | J Mol Biol |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663274/ https://ncbi.nlm.nih.gov/pubmed/28390900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.03.030 |
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