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Gain-of-function mutant p53 in cancer progression and therapy

p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite for cancer development. The p53 gene is the most frequently mutated gene in human cancers; p53 mutations occur in >50% of all human cancers and in almost every type of human cancers. Most of p53 mutations in canc...

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Опубликовано в: :J Mol Cell Biol
Главные авторы: Zhang, Cen, Liu, Juan, Xu, Dandan, Zhang, Tianliang, Hu, Wenwei, Feng, Zhaohui
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749743/
https://ncbi.nlm.nih.gov/pubmed/32722796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjaa040
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