Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis

Tumor suppressor p53 is the most frequently mutated gene in human cancer. Mutant p53 (mutp53) not only loses the tumor suppressive activity of wild type p53, but often gains new oncogenic activities to promote tumorigenesis, defined as mutp53 gain of function (GOF). While the concept of mutp53 GOF i...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Yue, Xuetian, Wu, Fangnan, Li, Yanchen, Liu, Juan, Boateng, Michael, Mandava, Kranthi, Zhang, Cen, Feng, Zhaohui, Gao, Jimin, Hu, Wenwei
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469461/
https://ncbi.nlm.nih.gov/pubmed/32275841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1749790
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