Evolutionary dynamics of tumor suppressor gene inactivation
Tumor suppressor genes (TSGs) are important gatekeepers that protect against somatic evolution of cancer. Losing both alleles of a TSG in a single cell represents a step toward cancer. We study how the kinetics of TSG inactivation depends on the population size of cells and the mutation rates for th...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC489986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15252197/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400747101 |
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