Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene

Apc is a gene associated with familial adenomatous polyposis coli (FAP) and its inactivation is a critical step in colorectal tumor formation. The protein product, adenomatous polyposis coli (APC), acts to down-regulate intracellular levels of β-catenin, a key signal transducer in the Wnt signaling....

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Detalhes bibliográficos
Main Authors: Hasegawa, Sumitaka, Sato, Tomoyuki, Akazawa, Hiroshi, Okada, Hitoshi, Maeno, Akiteru, Ito, Masaki, Sugitani, Yoshinobu, Shibata, Hiroyuki, Miyazaki, Jun-ichi, Katsuki, Motoya, Yamauchi, Yasutaka, Yamamura, Ken-ichi, Katamine, Shigeru, Noda, Tetsuo
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC117555/
https://ncbi.nlm.nih.gov/pubmed/11756652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012264999
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