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Evolutionary dynamics of tumor suppressor gene inactivation
Tumor suppressor genes (TSGs) are important gatekeepers that protect against somatic evolution of cancer. Losing both alleles of a TSG in a single cell represents a step toward cancer. We study how the kinetics of TSG inactivation depends on the population size of cells and the mutation rates for th...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC489986/ https://ncbi.nlm.nih.gov/pubmed/15252197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400747101 |
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