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The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer

Many cancers are characterized by chromosomal instability (CIN). This phenotype involves the deletion and duplication of chromosomes or chromosome parts and results in a high degree of aneuploidy. The role of CIN for cancer progression is a very important, yet unresolved question. It has been argued...

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Detalhes bibliográficos
Main Authors: Komarova, Natalia L., Wodarz, Dominik
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC406458/
https://ncbi.nlm.nih.gov/pubmed/15105448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401943101
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