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The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer
Many cancers are characterized by chromosomal instability (CIN). This phenotype involves the deletion and duplication of chromosomes or chromosome parts and results in a high degree of aneuploidy. The role of CIN for cancer progression is a very important, yet unresolved question. It has been argued...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC406458/ https://ncbi.nlm.nih.gov/pubmed/15105448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401943101 |
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