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Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy
To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick’s limit. We find that in the biologically relevant range of parameters, if the imbalance between cell division and death is moder...
Gorde:
| Argitaratua izan da: | Sci Rep |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4673423/ https://ncbi.nlm.nih.gov/pubmed/26647820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17660 |
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