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Evolutionary dynamics of tumor suppressor gene inactivation
Tumor suppressor genes (TSGs) are important gatekeepers that protect against somatic evolution of cancer. Losing both alleles of a TSG in a single cell represents a step toward cancer. We study how the kinetics of TSG inactivation depends on the population size of cells and the mutation rates for th...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC489986/ https://ncbi.nlm.nih.gov/pubmed/15252197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400747101 |
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