Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins
The electrophilic eicosanoids prostaglandins A(1) or A(2) impaired p53-dependent transcription of endogenous genes and exogenous p53-luciferase reporter plasmids in RKO and HCT 116 colon cancer cells. Cellular accumulation of genetically wild-type, but transcriptionally silent p53 varied as a functi...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16848/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908664/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160241897 |
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