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Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins

The electrophilic eicosanoids prostaglandins A(1) or A(2) impaired p53-dependent transcription of endogenous genes and exogenous p53-luciferase reporter plasmids in RKO and HCT 116 colon cancer cells. Cellular accumulation of genetically wild-type, but transcriptionally silent p53 varied as a functi...

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Bibliografski detalji
Glavni autori: Moos, P. J., Edes, K., Fitzpatrick, F. A.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC16848/
https://ncbi.nlm.nih.gov/pubmed/10908664
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