Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP

p53 inactivation is highly associated with tumorigenesis and drug resistance. Here, we identify a long noncoding RNA, the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP), as an inhibitor of p53. RMRP is overexpressed and associated with an unfavorable prognosis in colorectal ca...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Chen, Yajie, Hao, Qian, Wang, Shanshan, Cao, Mingming, Huang, Yingdan, Weng, Xiaoling, Wang, Jieqiong, Zhang, Zhen, He, Xianghuo, Lu, Hua, Zhou, Xiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307289/
https://ncbi.nlm.nih.gov/pubmed/34266953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2026813118
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