Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP

p53 inactivation is highly associated with tumorigenesis and drug resistance. Here, we identify a long noncoding RNA, the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP), as an inhibitor of p53. RMRP is overexpressed and associated with an unfavorable prognosis in colorectal ca...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Chen, Yajie, Hao, Qian, Wang, Shanshan, Cao, Mingming, Huang, Yingdan, Weng, Xiaoling, Wang, Jieqiong, Zhang, Zhen, He, Xianghuo, Lu, Hua, Zhou, Xiang
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307289/
https://ncbi.nlm.nih.gov/pubmed/34266953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2026813118
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