Rational development of a potent 15-lipoxygenase-1 inhibitor with in vitro and ex vivo anti-inflammatory properties

Human 15-lipoxygenase-1 (h-15-LOX-1) is an important mammalian lipoxygenase and plays an important role in several inflammatory lung diseases such as asthma, COPD and chronic bronchitis. Novel potent inhibitors of h-15-LOX-1 are required to explore the role of this enzyme further and to enable drug...

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Vydáno v:J Med Chem
Hlavní autoři: Eleftheriadis, Nikolaos, Neochoritis, Constantinos G., Leus, Niek G.J., van der Wouden, Petra E., Dömling, Alexander, Dekker, Frank J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872822/
https://ncbi.nlm.nih.gov/pubmed/26331552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01121
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