Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity

[Image: see text] Various mechanisms for regulated cell death include the formation of oxidative mediators such as lipid peroxides and nitric oxide (NO). In this respect, 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that catalyzes the formation of lipid peroxides. The actions of these peroxides are...

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Détails bibliographiques
Publié dans:J Med Chem
Auteurs principaux: Guo, Hao, Verhoek, Iris C., Prins, Gerian G. H., van der Vlag, Ramon, van der Wouden, Petra E., van Merkerk, Ronald, Quax, Wim J., Olinga, Peter, Hirsch, Anna K. H., Dekker, Frank J.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511944/
https://ncbi.nlm.nih.gov/pubmed/30964295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00212
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