Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity

[Image: see text] Various mechanisms for regulated cell death include the formation of oxidative mediators such as lipid peroxides and nitric oxide (NO). In this respect, 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that catalyzes the formation of lipid peroxides. The actions of these peroxides are...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Guo, Hao, Verhoek, Iris C., Prins, Gerian G. H., van der Vlag, Ramon, van der Wouden, Petra E., van Merkerk, Ronald, Quax, Wim J., Olinga, Peter, Hirsch, Anna K. H., Dekker, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511944/
https://ncbi.nlm.nih.gov/pubmed/30964295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00212
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