Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells

Oncogenic NRAS mutations are frequent in melanoma and lead to increased downstream signaling and uncontrolled cell proliferation. Since the direct inhibition of NRAS is not possible yet, modulators of NRAS posttranslational modifications have become an area of interest. Specifically, interfering wit...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Vujic, Igor, Sanlorenzo, Martina, Esteve-Puig, Rosaura, Vujic, Marin, Kwong, Andrew, Tsumura, Aaron, Murphy, Ryan, Moy, Adrian, Posch, Christian, Monshi, Babak, Rappersberger, Klemens, Ortiz-Urda, Susana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872786/
https://ncbi.nlm.nih.gov/pubmed/26771141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6907
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