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Searching for the Chokehold of NRAS Mutant Melanoma
Up to 18% of melanomas harbor mutations in the neuroblastoma rat-sarcoma homolog (NRAS). Yet, decades of research aimed to interfere with oncogenic RAS signaling have been largely disappointing and have not resulted in meaningful clinical outputs. Recent advances in disease modeling, structural biol...
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| 發表在: | J Invest Dermatol |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4921268/ https://ncbi.nlm.nih.gov/pubmed/27160069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.03.006 |
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