Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer

Attempts to directly block the mutant neuroblastoma rat sarcoma oncogene (NRAS) protein, a driving mutation in many cancer types, have been unsuccessful. Current treatments focus on inhibition of different components of NRAS' two main downstream cascades: PI3K/AKT/mTOR and MAPK. Here we test a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vujic, Igor, Sanlorenzo, Martina, Posch, Christian, Esteve-Puig, Rosaura, Yen, Adam J., Kwong, Andrew, Tsumura, Aaron, Murphy, Ryan, Rappersberger, Klemens, Ortiz-Urda, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359268/
https://ncbi.nlm.nih.gov/pubmed/25504439
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