Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells

In melanoma, mutant and thereby constantly active neuroblastoma rat sarcoma (NRAS) affects 15—20% of tumors, contributing to tumor initiation, growth, invasion, and metastasis. Recent therapeutic approaches aim to mimic RAS extinction by interfering with critical signaling pathways downstream of the...

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Udgivet i:J Invest Dermatol
Main Authors: Posch, Christian, Sanlorenzo, Martina, Vujic, Igor, Oses-Prieto, Juan A., Cholewa, Brian D., Kim, Sarasa T., Ma, Jeffrey, Lai, Kevin, Zekhtser, Mitchell, Esteve-Puig, Rosaura, Green, Gary, Chand, Shreya, Burlingame, Alma L., Panzer-Grümayer, Renate, Rappersberger, Klemens, Ortiz-Urda, Susana
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373467/
https://ncbi.nlm.nih.gov/pubmed/27251789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.05.098
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