Pharmacological inhibitors of c-KIT block mutant c-KIT mediated migration of melanocytes and melanoma cells in vitro and in vivo

Mutations in the receptor tyrosine kinase c-KIT (KIT) are frequent oncogenic alterations in melanoma and are predominantly detected in tumors of acral, mucosal, and chronically sun-damaged skin. Research indicates that melanocytes with aberrant KIT signaling can be found in the distant periphery of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Posch, Christian, Moslehi, Homayoun, Sanlorenzo, Martina, Green, Gary, Vujic, Igor, Panzer-Grümayer, Renate, Rappersberger, Klemens, Ortiz-Urda, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216770/
https://ncbi.nlm.nih.gov/pubmed/27322141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10001
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