Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells

Oncogenic NRAS mutations are frequent in melanoma and lead to increased downstream signaling and uncontrolled cell proliferation. Since the direct inhibition of NRAS is not possible yet, modulators of NRAS posttranslational modifications have become an area of interest. Specifically, interfering wit...

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Опубликовано в: :Oncotarget
Главные авторы: Vujic, Igor, Sanlorenzo, Martina, Esteve-Puig, Rosaura, Vujic, Marin, Kwong, Andrew, Tsumura, Aaron, Murphy, Ryan, Moy, Adrian, Posch, Christian, Monshi, Babak, Rappersberger, Klemens, Ortiz-Urda, Susana
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872786/
https://ncbi.nlm.nih.gov/pubmed/26771141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6907
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