Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells

Oncogenic NRAS mutations are frequent in melanoma and lead to increased downstream signaling and uncontrolled cell proliferation. Since the direct inhibition of NRAS is not possible yet, modulators of NRAS posttranslational modifications have become an area of interest. Specifically, interfering wit...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vujic, Igor, Sanlorenzo, Martina, Esteve-Puig, Rosaura, Vujic, Marin, Kwong, Andrew, Tsumura, Aaron, Murphy, Ryan, Moy, Adrian, Posch, Christian, Monshi, Babak, Rappersberger, Klemens, Ortiz-Urda, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872786/
https://ncbi.nlm.nih.gov/pubmed/26771141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6907
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