Delineation of MGMT Hypermethylation as a Biomarker for Veliparib-Mediated Temozolomide-Sensitizing Therapy of Glioblastoma

BACKGROUND: Sensitizing effects of poly-ADP-ribose polymerase inhibitors have been studied in several preclinical models, but a clear understanding of predictive biomarkers is lacking. In this study, in vivo efficacy of veliparib combined with temozolomide (TMZ) was evaluated in a large panel of gli...

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Pubblicato in:J Natl Cancer Inst
Autori principali: Gupta, Shiv K., Kizilbash, Sani H., Carlson, Brett L., Mladek, Ann C., Boakye-Agyeman, Felix, Bakken, Katrina K., Pokorny, Jenny L., Schroeder, Mark A., Decker, Paul A., Cen, Ling, Eckel-Passow, Jeanette E., Sarkar, Gobinda, Ballman, Karla V., Reid, Joel M., Jenkins, Robert B., Verhaak, Roeland G., Sulman, Erik P., Kitange, Gaspar J., Sarkaria, Jann N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862419/
https://ncbi.nlm.nih.gov/pubmed/26615020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv369
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