RM-04 RETINOBLASTOMA BINDING PROTEIN 4 (RBBP4) MODULATES TEMOZOLOMIDE RESPONSE THROUGH REGULATION OF MGMT EXPRESSION IN GLIOBLASTOMA

Through shRNA library screen we identified RBBP4 as a modulator of TMZ response in glioblastoma (GBM). Consequently, we investigated the mechanisms whereby RBBP4 modulates TMZ response using shRNA to silence this gene in MGMT-expressing T98G and U138 GBM cells. The cytotoxicity was evaluated using f...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Kitange, Gaspar, Schroeder, Mark, Sarkaria, Jann
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2014
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Abstracts
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218560/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou273.4
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