Evaluation of MGMT Promoter Methylation Status and Correlation with Temozolomide Response in Orthotopic Glioblastoma Xenograft Model

CpG methylation within the O6-methylguanine-DNA-methyltransferase (MGMT) promoter is associated with enhanced survival of glioblastoma multiforme (GBM) patients treated with temozolomide (TMZ). Although MGMT promoter is methylated in ~50% of GBM, several studies have reported a lack of correlation b...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Kitange, Gaspar J., Carlson, Brett L., Mladek, Ann C., Decker, Paul A., Schroeder, Mark A., Wu, Wenting, Grogan, Patrick T., Giannini, Caterina, Ballman, Karla V., Buckner, Jan C., James, C. David, Sarkaria, Jann N.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2008
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790867/
https://ncbi.nlm.nih.gov/pubmed/19011762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-008-9737-8
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