Evaluation of MGMT Promoter Methylation Status and Correlation with Temozolomide Response in Orthotopic Glioblastoma Xenograft Model

CpG methylation within the O6-methylguanine-DNA-methyltransferase (MGMT) promoter is associated with enhanced survival of glioblastoma multiforme (GBM) patients treated with temozolomide (TMZ). Although MGMT promoter is methylated in ~50% of GBM, several studies have reported a lack of correlation b...

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Autores principales: Kitange, Gaspar J., Carlson, Brett L., Mladek, Ann C., Decker, Paul A., Schroeder, Mark A., Wu, Wenting, Grogan, Patrick T., Giannini, Caterina, Ballman, Karla V., Buckner, Jan C., James, C. David, Sarkaria, Jann N.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790867/
https://ncbi.nlm.nih.gov/pubmed/19011762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-008-9737-8
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