Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts()

PURPOSE: The therapeutic benefit of temozolomide (TMZ) in glioblastoma (GBM) is limited by resistance. The goal of this study was to elucidate mechanisms of TMZ resistance in GBM. EXPERIMENTAL DESIGN: We developed an in vivo GBM model of TMZ resistance and used paired parental and TMZ resistant tumo...

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Detalhes bibliográficos
Main Authors: Kitange, Gaspar J., Mladek, Ann C., Carlson, Brett L., Schroeder, Mark A., Pokorny, Jenny L., Cen, Ling, Decker, Paul A., Wu, Wenting, Lomberk, Gwen A., Gupta, Shiv K., Urrutia, Raul A., Sarkaria, Jann N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716364/
https://ncbi.nlm.nih.gov/pubmed/22675172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0560
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